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Increased serum estradiol

MedGen UID:
717742
•Concept ID:
C1295643
•
Finding
Synonyms: Estradiol level above reference range; Increased estradiol level; Increased serum oestradiol
SNOMED CT: Increased estradiol level (131065003); Estradiol level above reference range (131065003)
 
HPO: HP:0025134

Definition

An elevation above normal limits of the concentration of estradiol in the circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased serum estradiol

Conditions with this feature

Estrogen resistance syndrome
MedGen UID:
815580
•Concept ID:
C3809250
•
Disease or Syndrome
Estrogen resistance (ESTRR) is characterized by absence of puberty with elevated estradiol and gonadotropic hormones, as well as markedly delayed bone maturation. Female patients show absent breast development, small uterus, and enlarged multicystic ovaries; male patients may show small testes (Bernard et al., 2017). Some patients exhibit continued growth into adulthood (Smith et al., 1994).
See: Condition Record
Estrogen resistance syndrome

Professional guidelines

PubMed

Human Bone Marrow Derived-Mesenchymal Stem Cells Treatment for Autoimmune Premature Ovarian Insufficiency.
Ma WQ, Zhuo AP, Xiao YL, Gao M, Yang YT, Tang LC, Wu YH, Tian D, Fu XF
Stem Cell Rev Rep 2024 Feb;20(2):538-553. Epub 2023 Dec 4 doi: 10.1007/s12015-023-10629-8. PMID: 38049593
Efficacy of proline in the treatment of menopause.
Nam SY, Yoou MS, Kim HM, Jeong HJ
Exp Biol Med (Maywood) 2016 Mar;241(6):611-9. Epub 2016 Jan 31 doi: 10.1177/1535370216629011. PMID: 26830682Free PMC Article
Management of urogenital atrophy in breast cancer patients: a systematic review of available evidence from randomized trials.
Mazzarello S, Hutton B, Ibrahim MFK, Jacobs C, Shorr R, Smith S, Ng T, Clemons M
Breast Cancer Res Treat 2015 Jul;152(1):1-8. Epub 2015 May 24 doi: 10.1007/s10549-015-3434-z. PMID: 26003182

Recent clinical studies

Etiology

Serum Hormone Concentrations in Transgender Youth Receiving Estradiol.
Sumerwell C, Carlin K, Walsh E, Hodax JK
Endocr Pract 2024 Feb;30(2):155-159. Epub 2023 Nov 27 doi: 10.1016/j.eprac.2023.11.011. PMID: 38029927
Serum estradiol concentration, estradiol-to-progesterone ratio and sputum IL-5 and IL-8 concentrations are increased in luteal phase of the menstrual cycle in perimenstrual asthma patients.
Semik-Orzech A, Skoczyński S, Pierzchała W
Eur Ann Allergy Clin Immunol 2017 Jul;49(4):161-170. doi: 10.23822/eurannaci.1764-1489.09. PMID: 28752719
Efficacy of proline in the treatment of menopause.
Nam SY, Yoou MS, Kim HM, Jeong HJ
Exp Biol Med (Maywood) 2016 Mar;241(6):611-9. Epub 2016 Jan 31 doi: 10.1177/1535370216629011. PMID: 26830682Free PMC Article
Serum estradiol levels predict survival and acute kidney injury in patients with septic shock--a prospective study.
Feng JY, Liu KT, Abraham E, Chen CY, Tsai PY, Chen YC, Lee YC, Yang KY
PLoS One 2014;9(6):e97967. Epub 2014 Jun 6 doi: 10.1371/journal.pone.0097967. PMID: 24904990Free PMC Article
The effect of estradiol and progesterone on knee and ankle joint laxity.
Beynnon BD, Bernstein IM, Belisle A, Brattbakk B, Devanny P, Risinger R, Durant D
Am J Sports Med 2005 Sep;33(9):1298-304. Epub 2005 Jul 7 doi: 10.1177/0363546505275149. PMID: 16002485

Diagnosis

Serum estradiol concentration, estradiol-to-progesterone ratio and sputum IL-5 and IL-8 concentrations are increased in luteal phase of the menstrual cycle in perimenstrual asthma patients.
Semik-Orzech A, Skoczyński S, Pierzchała W
Eur Ann Allergy Clin Immunol 2017 Jul;49(4):161-170. doi: 10.23822/eurannaci.1764-1489.09. PMID: 28752719
Serum estradiol levels predict survival and acute kidney injury in patients with septic shock--a prospective study.
Feng JY, Liu KT, Abraham E, Chen CY, Tsai PY, Chen YC, Lee YC, Yang KY
PLoS One 2014;9(6):e97967. Epub 2014 Jun 6 doi: 10.1371/journal.pone.0097967. PMID: 24904990Free PMC Article
Raloxifene treatment is associated with increased serum estradiol and decreased bone remodeling in healthy middle-aged men with low sex hormone levels.
Uebelhart B, Herrmann F, Pavo I, Draper MW, Rizzoli R
J Bone Miner Res 2004 Sep;19(9):1518-24. Epub 2004 May 3 doi: 10.1359/JBMR.040503. PMID: 15312253
Spontaneous puberty in 46,XX subjects with congenital lipoid adrenal hyperplasia. Ovarian steroidogenesis is spared to some extent despite inactivating mutations in the steroidogenic acute regulatory protein (StAR) gene.
Fujieda K, Tajima T, Nakae J, Sageshima S, Tachibana K, Suwa S, Sugawara T, Strauss JF 3rd
J Clin Invest 1997 Mar 15;99(6):1265-71. doi: 10.1172/JCI119284. PMID: 9077535Free PMC Article

Therapy

HLDF-6 peptides exhibit neuroprotective effects in the experimental model of preclinical Parkinson's disease.
Zolotarev YA, Shram SI, Dadayan AK, Dolotov OV, Markov DD, Nagaev IY, Kudrin VS, Narkevich VB, Sokolov OY, Kost NV
Neuropeptides 2022 Dec;96:102287. Epub 2022 Sep 15 doi: 10.1016/j.npep.2022.102287. PMID: 36280440
Efficacy of proline in the treatment of menopause.
Nam SY, Yoou MS, Kim HM, Jeong HJ
Exp Biol Med (Maywood) 2016 Mar;241(6):611-9. Epub 2016 Jan 31 doi: 10.1177/1535370216629011. PMID: 26830682Free PMC Article
Management of urogenital atrophy in breast cancer patients: a systematic review of available evidence from randomized trials.
Mazzarello S, Hutton B, Ibrahim MFK, Jacobs C, Shorr R, Smith S, Ng T, Clemons M
Breast Cancer Res Treat 2015 Jul;152(1):1-8. Epub 2015 May 24 doi: 10.1007/s10549-015-3434-z. PMID: 26003182
Serum estradiol levels predict survival and acute kidney injury in patients with septic shock--a prospective study.
Feng JY, Liu KT, Abraham E, Chen CY, Tsai PY, Chen YC, Lee YC, Yang KY
PLoS One 2014;9(6):e97967. Epub 2014 Jun 6 doi: 10.1371/journal.pone.0097967. PMID: 24904990Free PMC Article
Raloxifene treatment is associated with increased serum estradiol and decreased bone remodeling in healthy middle-aged men with low sex hormone levels.
Uebelhart B, Herrmann F, Pavo I, Draper MW, Rizzoli R
J Bone Miner Res 2004 Sep;19(9):1518-24. Epub 2004 May 3 doi: 10.1359/JBMR.040503. PMID: 15312253

Prognosis

Serum estradiol levels predict survival and acute kidney injury in patients with septic shock--a prospective study.
Feng JY, Liu KT, Abraham E, Chen CY, Tsai PY, Chen YC, Lee YC, Yang KY
PLoS One 2014;9(6):e97967. Epub 2014 Jun 6 doi: 10.1371/journal.pone.0097967. PMID: 24904990Free PMC Article
Gynecomastia during imatinib mesylate treatment for gastrointestinal stromal tumor: a rare adverse event.
Liu H, Liao G, Yan Z
BMC Gastroenterol 2011 Nov 2;11:116. doi: 10.1186/1471-230X-11-116. PMID: 22047550Free PMC Article
Cyclin D1 regulates hepatic estrogen and androgen metabolism.
Mullany LK, Hanse EA, Romano A, Blomquist CH, Mason JI, Delvoux B, Anttila C, Albrecht JH
Am J Physiol Gastrointest Liver Physiol 2010 Jun;298(6):G884-95. Epub 2010 Mar 25 doi: 10.1152/ajpgi.00471.2009. PMID: 20338923Free PMC Article
Raloxifene treatment is associated with increased serum estradiol and decreased bone remodeling in healthy middle-aged men with low sex hormone levels.
Uebelhart B, Herrmann F, Pavo I, Draper MW, Rizzoli R
J Bone Miner Res 2004 Sep;19(9):1518-24. Epub 2004 May 3 doi: 10.1359/JBMR.040503. PMID: 15312253

Clinical prediction guides

Serum Hormone Concentrations in Transgender Youth Receiving Estradiol.
Sumerwell C, Carlin K, Walsh E, Hodax JK
Endocr Pract 2024 Feb;30(2):155-159. Epub 2023 Nov 27 doi: 10.1016/j.eprac.2023.11.011. PMID: 38029927
Serum estradiol concentration, estradiol-to-progesterone ratio and sputum IL-5 and IL-8 concentrations are increased in luteal phase of the menstrual cycle in perimenstrual asthma patients.
Semik-Orzech A, Skoczyński S, Pierzchała W
Eur Ann Allergy Clin Immunol 2017 Jul;49(4):161-170. doi: 10.23822/eurannaci.1764-1489.09. PMID: 28752719
Serum estradiol levels predict survival and acute kidney injury in patients with septic shock--a prospective study.
Feng JY, Liu KT, Abraham E, Chen CY, Tsai PY, Chen YC, Lee YC, Yang KY
PLoS One 2014;9(6):e97967. Epub 2014 Jun 6 doi: 10.1371/journal.pone.0097967. PMID: 24904990Free PMC Article
Cyclin D1 regulates hepatic estrogen and androgen metabolism.
Mullany LK, Hanse EA, Romano A, Blomquist CH, Mason JI, Delvoux B, Anttila C, Albrecht JH
Am J Physiol Gastrointest Liver Physiol 2010 Jun;298(6):G884-95. Epub 2010 Mar 25 doi: 10.1152/ajpgi.00471.2009. PMID: 20338923Free PMC Article
Raloxifene treatment is associated with increased serum estradiol and decreased bone remodeling in healthy middle-aged men with low sex hormone levels.
Uebelhart B, Herrmann F, Pavo I, Draper MW, Rizzoli R
J Bone Miner Res 2004 Sep;19(9):1518-24. Epub 2004 May 3 doi: 10.1359/JBMR.040503. PMID: 15312253

Recent systematic reviews

Management of urogenital atrophy in breast cancer patients: a systematic review of available evidence from randomized trials.
Mazzarello S, Hutton B, Ibrahim MFK, Jacobs C, Shorr R, Smith S, Ng T, Clemons M
Breast Cancer Res Treat 2015 Jul;152(1):1-8. Epub 2015 May 24 doi: 10.1007/s10549-015-3434-z. PMID: 26003182

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